Marcos R M Fontes Selected Research

Crotoxin

11/2017	Neuromuscular paralysis by the basic phospholipase A2 subunit of crotoxin from Crotalus durissus terrificus snake venom needs its acid chaperone to concurrently inhibit acetylcholine release and produce muscle blockage.
6/2010	Crotoxin: novel activities for a classic beta-neurotoxin.
8/2008	Insights into the role of oligomeric state on the biological activities of crotoxin: crystal structure of a tetrameric phospholipase A2 formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom.

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Marcos R M Fontes Research Topics

Disease

14	Snake Bites (Snake Bite) 11/2021 - 09/2005
11	Myotoxicity 08/2021 - 12/2007
6	Necrosis 12/2020 - 03/2004
5	Hemorrhage 12/2020 - 03/2004
5	Edema (Dropsy) 03/2011 - 08/2002
4	Neoplasms (Cancer) 01/2019 - 03/2006
3	Pain (Aches) 12/2020 - 03/2004
2	Inflammation (Inflammations) 01/2022 - 12/2017
2	Cardiotoxicity 02/2011 - 06/2010
1	Ischemia 12/2020
1	Blister (Bulla) 12/2020
1	Rupture 03/2020
1	Leishmaniasis 07/2019
1	Acquired Immunodeficiency Syndrome (AIDS) 01/2019
1	Colonic Neoplasms (Colon Cancer) 03/2018
1	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2017
1	Paralysis (Palsy) 11/2017
1	Cockayne Syndrome (Syndrome, Cockayne) 01/2016
1	Xeroderma Pigmentosum (Kaposi's Disease) 01/2016
1	Wounds and Injuries (Trauma) 01/2015
1	Malaria 08/2010
1	Renal Insufficiency (Renal Failure) 08/2008
1	Nervous System Diseases (Neurological Disorders) 08/2008
1	Adenocarcinoma 03/2006
1	Leukemia 03/2006

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 12/2020 - 03/2004
9	Antivenins (Antivenoms)IBA 11/2021 - 02/2011
8	Snake Venoms (Snake Venom)IBA 01/2021 - 03/2004
7	VenomsIBA 12/2017 - 09/2005
6	Phospholipases A2 (Phospholipase A2)IBA 11/2017 - 09/2005
3	EnzymesIBA 12/2020 - 03/2004
3	Phospholipases (Phospholipase)IBA 12/2017 - 01/2017
3	CrotoxinIBA 11/2017 - 08/2008
2	Metalloproteases (Metalloproteinases)IBA 12/2020 - 07/2007
2	Complement System Proteins (Complement)IBA 03/2020 - 01/2019
2	Phospholipids (Phosphatides)FDA LinkGeneric 12/2017 - 02/2011
2	IonsIBA 01/2017 - 12/2007
2	ZincIBA 01/2017 - 07/2007
2	Biological ProductsIBA 12/2013 - 06/2010
2	Phospholipases AIBA 03/2011 - 02/2011
2	Peptides (Polypeptides)IBA 03/2006 - 03/2004
1	InterleukinsIBA 01/2022
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2022
1	Interleukin-10 (Interleukin 10)IBA 01/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022
1	C-Type Lectins (C-Type Lectin)IBA 01/2022
1	InflammasomesIBA 01/2022
1	NeurotoxinsIBA 08/2021
1	PhytochemicalsIBA 08/2021
1	Gallic AcidIBA 08/2021
1	caftaric acidIBA 03/2020
1	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2019
1	SERPIN-B5 (maspin)IBA 01/2019
1	Nuclear Localization Signals (Nuclear Localization Signal)IBA 01/2019
1	AcidsIBA 11/2017
1	Acetylcholine (Acetylcholine Chloride)FDA Link 11/2017
1	QuinolonesIBA 02/2016
1	piratoxin IIBA 01/2015
1	caffeic acidIBA 02/2011
1	protoporphyrin IXIBA 08/2010
1	Heme (Haem)IBA 08/2010
1	hemozoinIBA 08/2010
1	Analgesics (Analgesic Drugs)IBA 06/2010
1	Caseins (Casein)FDA Link 12/2007
1	CollagenIBA 12/2007
1	FibrinIBA 12/2007
1	Fibrinogen (Factor I)FDA Link 12/2007
1	GelatinIBA 12/2007
1	Antiparasitic Agents (Antiparasitics)IBA 03/2006
1	bothropstoxinIBA 09/2005
1	bothropstoxin IIIBA 09/2005
1	Protein Isoforms (Isoforms)IBA 09/2005
1	Indomethacin (Indometacin)FDA LinkGeneric 05/2004
1	Dexamethasone (Maxidex)FDA LinkGeneric 05/2004
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 05/2004
1	Edetic Acid (EDTA)FDA Link 08/2002

Therapy/Procedure

6	Therapeutics 03/2020 - 02/2011
3	Traditional Medicine (Folk Remedies) 01/2015 - 09/2005
1	Surgical Amputation (Amputations) 12/2020
1	Analgesia 12/2017